1-Brommethyl-4-(1,1-dimethylpropyl)-benzol

Base Information

• Chemical Name: 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol
• CAS No.: 149530-71-2
• Molecular Formula: C₁₂H₁₇Br
• Molecular Weight: 241.171
• Mol file: 149530-71-2.mol

Synonyms:1-Brommethyl-4-(1,1-dimethylpropyl)-benzol

Chemical Property of 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol

There total 4 articles about 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-t-amylbenzylamine → 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol (149530-71-2)

Guidance literature:

With ethyl bromide; oxalic acid; copper(I) bromide; at 85 ℃; for 19h; Temperature;

Reference yield: 72.0%

4-(1,1-dimethylpropyl)toluene (4237-70-1) → 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol (149530-71-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 9h; Heating;

DOI:10.1002/ardp.19933260608

Reference yield:

tert-Amyl alcohol (75-85-4) → 1-Brommethyl-4-(1,1-dimethylpropyl)-benzol (149530-71-2)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / 0.33 h

2: TiCl₄ / 2 h / 40 °C

3: 72 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 9 h / Heating

With hydrogenchloride; N-Bromosuccinimide; titanium tetrachloride; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1002/ardp.19933260608

upstream raw materials:

4-(1,1-dimethylpropyl)toluene

tert-Amyl alcohol

2-methyl-2-butylchloride

Downstream raw materials:

2-methyl-3-(4-(tert-pentyl)phenyl)propanal

Refernces

• 1、 Stanetty,Koller,Purstinger,Grubner. "Synthesis of new 7-benzofuranmethanamines as heterocyclic analogues of the squalenepoxidase-inhibitor Butenafine". . p. 351 - 358. Retrieved 2007/10/02.