Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Base Information

Chemical Name:Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester
CAS No.:80360-66-3
Molecular Formula:C₂₈H₃₁NO₅
Molecular Weight:461.558
Hs Code.:

Synonyms:Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Suppliers and Price of Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

There total 7 articles about Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 80361-04-2
(E,E)-4-methyl-2,4-hexadien-1-yl ethyl carbonate

: 80360-64-1
1-Benzoyl-5-benzyl-1,5-dihydro-pyrrol-2-one

: Carbonic acid (3aR,4R,7R,7aS)-2-benzoyl-3-benzyl-6,7-dimethyl-1-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

: 80360-66-3
Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Guidance literature:: With 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; In toluene; at 150 ℃; for 82h;
DOI:10.1021/jo00347a034

Reference yield:

: 70849-69-3,30338-90-0,57258-51-2
(2E,4E)-4-methylhexa-2,4-dien-1-ol

: 80360-66-3
Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / pyridine / 1 h / Ambient temperature

2: 16 percent / 2,5-di-tert-butylhydroquinone / toluene / 82 h / 150 °C

With pyridine; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; In toluene;
DOI:10.1021/jo00347a034

Reference yield:

: 1795-96-6
phenylalanine ethyl ester

: 80360-66-3
Carbonic acid (3aR,4S,7S,7aR)-2-benzoyl-1-benzyl-6,7-dimethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-isoindol-4-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / K₂CO₃ / diethyl ether; H₂O / ice bath

2: sodium ethanolate / ethanol; diethyl ether / 15 h / Ambient temperature

3: 90 percent / acetonitrile; H₂O / 2 h / 70 °C

4: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature

5: n-BuLi / tetrahydrofuran; hexane / -78 - 25 °C

6: triethylamine / tetrahydrofuran; hexane

7: 16 percent / 2,5-di-tert-butylhydroquinone / toluene / 82 h / 150 °C

With n-butyllithium; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; sodium ethanolate; sodium cyanoborohydride; potassium carbonate; triethylamine; chloroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; toluene; acetonitrile;
DOI:10.1021/jo00347a034