(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

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Chemical Name:(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran
CAS No.:1195787-98-4
Molecular Formula:C₅₅H₁₀₄O₉Si₅
Molecular Weight:1049.85
Hs Code.:

(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

Synonyms:(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

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Chemical Property of (2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

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Technology Process of (2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

There total 3 articles about (2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 1195788-06-7
C₄₃H₇₆O₉Si₃

: 1195787-98-4
(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol401176a

Reference yield: 96.0%

: (1S,2R)-1-{(2S,3R,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tert-butyldimethylsilyloxy)-tetrahydropyran-2-yl}-3-(4-methoxybenzyloxy)propane-1,2-diol

: 69739-34-0
t-butyldimethylsiyl triflate

: 1195787-98-4
(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo901793f

Reference yield:

: C₄₃H₇₄O₇Si₃

: 1195787-98-4
(2R,3S,4R,6R)-6-[(1R)-2-benzyloxy-1-(tert-butyldimethylsilyloxy)-ethyl]-3,4-bis-(tertbutyldimethylsilyloxy)-2-[(1R,2R)-1,2-bis-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propyl]-tetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: potassium osmate(VI) dihydrate; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; K₃Fe(CN)6; potassium carbonate; methanesulfonamide / tert-butyl alcohol; water / 18 h / 0 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; potassium osmate(VI) dihydrate; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; K₃Fe(CN)6; methanesulfonamide; potassium carbonate; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol401176a