(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

Base Information

Chemical Name:(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione
CAS No.:1098197-85-3
Molecular Formula:C₂₆H₃₀N₂O₂
Molecular Weight:402.536
Hs Code.:

Synonyms:(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

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Chemical Property of (2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

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Technology Process of (2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

There total 2 articles about (2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1098197-77-3
(4E,6R,7S,11E,13R,14S)-6,13-dimethyl-7,14-diphenyl-1,8-diazacyclotetradeca-4,11-diene-2,9-dione

: 1098197-85-3
(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

: 1098198-13-0
C₂₆H₃₀N₂O₂

: 1098198-11-8
C₂₆H₃₀N₂O₂

Guidance literature:: With sodium t-butanolate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol802729f

Reference yield:

: 1098197-90-0
C₂₆H₃₀N₂O₂

: 1098197-85-3
(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

: 1098198-13-0
C₂₆H₃₀N₂O₂

: 1098198-11-8
C₂₆H₃₀N₂O₂

Guidance literature:: With sodium t-butanolate; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;
DOI:10.1021/ol802729f

Reference yield: 87.0%

: 1098197-85-3
(2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

: 106-95-6
allyl bromide

: 1098197-97-7
(2R,3S,6S,6aS,8R,9S,12S,12aS)-6,12-diallyl-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione

Guidance literature:: (2R,3S,6aS,8R,9S,12aS)-2,8-dimethyl-3,9-diphenyloctahydrodipyrrolo[1,2-a:1',2'-e][1,5]diazocine-5,11(1H,6H)-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -30 ℃; Inert atmosphere;

allyl bromide; In tetrahydrofuran; at -78 - 0 ℃; for 2h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol802729f