2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester
CAS No.:851370-26-8
Molecular Formula:C₃₃H₅₂O₈
Molecular Weight:576.771
Hs Code.:

2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Synonyms:2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

There total 12 articles about 2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851370-24-6
2,2-Dimethyl-propionic acid (2R,3S)-4-[(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-trifluoromethanesulfonyloxy-6-triisopropylsilanyloxymethyl-5,6-dihydro-4H-pyran-3-yl]-2,3-dimethyl-butyl ester

: 851370-26-8
2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(Ph₃P)4; NaOH / dioxane / 3 h / 60 °C

2: 1.97 g / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 0.5 h / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2006.08.083

Reference yield:

: 851370-34-8
2,2-Dimethyl-propionic acid (2R,3R)-4-hydroxy-2,3-dimethyl-butyl ester

: 851370-26-8
2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / I₂; Ph₃P; imidazole / CH₂Cl₂ / 14 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

2.2: 85 percent / DMPU / tetrahydrofuran / 3 h / 0 °C

3.1: 95 percent / KHMDS / tetrahydrofuran / -78 °C

4.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

4.2: ZnCl₂ / tetrahydrofuran; pentane / 0.08 h

4.3: 75 percent / NMP / Pd[P(t-Bu)3]2 / tetrahydrofuran; pentane / 0.5 h / -78 - 20 °C

5.1: 91 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; potassium hexamethylsilazane; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; pentane; 4.3: Negishi coupling;
DOI:10.1021/ol050321l

Reference yield:

: 851370-21-3
2,2-Dimethyl-propionic acid (2R,3R)-4-iodo-2,3-dimethyl-butyl ester

: 851370-26-8
2,2-Dimethyl-propionic acid (2R,3S)-4-{(R)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-5,6-dihydro-4H-pyran-3-yl}-2,3-dimethyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C

1.2: 85 percent / DMPU / tetrahydrofuran / 3 h / 0 °C

2.1: 95 percent / KHMDS / tetrahydrofuran / -78 °C

3.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

3.2: ZnCl₂ / tetrahydrofuran; pentane / 0.08 h

3.3: 75 percent / NMP / Pd[P(t-Bu)3]2 / tetrahydrofuran; pentane / 0.5 h / -78 - 20 °C

4.1: 91 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; pentane; 3.3: Negishi coupling;
DOI:10.1021/ol050321l