Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-

Base Information

• Chemical Name: Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-
• CAS No.: 209982-91-2
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.131
• Mol file: 209982-91-2.mol

Synonyms:S-(+)-3,5-difluoromandelic acid

Chemical Property of Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Benzeneaceticacid,3,5-difluoro-α-hydroxy-,(αS)- >97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-

There total 2 articles about Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl S-(+/-)-3,5-difluoromandelate (209982-92-3) → S-(+)-3,5-difluoromandelic acid (209982-91-2)

Guidance literature:

With lithium hydroxide; In aqueous THF;

Reference yield:

S-(+)-3.5-Difluoromandelic Acid (132741-31-2) → 2-(3,5-difluorophenyl)-2-oxoacetic acid + S-(+)-3,5-difluoromandelic acid (209982-91-2)

Guidance literature:

With D-lactate oxidase from Gluconobacter oxydans 621H; oxygen; catalase; In aq. buffer; at 30 ℃; for 12h; pH=7.4; Reagent/catalyst; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/cctc.201600536

Reference yield:

5-(L-Alanyl)-amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one Hydrochloride + S-(+)-3,5-difluoromandelic acid (209982-91-2) → 5-{N'-[(S)-3,5-difluoromandelyl]-L-alaninyl}amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (1027299-17-7)

Guidance literature:

upstream raw materials:

Methyl S-(+/-)-3,5-difluoromandelate

S-(+)-3.5-Difluoromandelic Acid

Downstream raw materials:

(S)-2-{(S)-2-[(S)-2-(3,5-Difluoro-phenyl)-2-hydroxy-acetylamino]-propionylamino}-hexanoic acid methyl ester

C₂₁H₂₀F₂N₄O₄

BMS-433796

5-{N'-[(S)-3,5-difluoromandelyl]-L-alaninyl}amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

Refernces

• 1、 -. "CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS". Page/Page column 67. . Retrieved 2009/02/10.
• 2、 -. "Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds". . . Retrieved 2008/06/13.