methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

Base Information

Chemical Name:methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate
CAS No.:1365721-14-7
Molecular Formula:C₂₀H₂₁NO₅S
Molecular Weight:387.456
Hs Code.:

Synonyms:methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

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Chemical Property of methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

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Technology Process of methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

There total 6 articles about methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1353433-14-3
5-isopropyl-3-methylbenzofuran-2-sulfonyl chloride

: 619-45-4
4-methoxycarbonyl aniline

: 1365721-14-7
methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

Guidance literature:: With pyridine; In acetonitrile; at 50 ℃;

Reference yield:

: 99-89-8
4-Isopropylphenol

: 1365721-14-7
methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid; N-iodo-succinimide / dichloromethane / 20 °C

2: potassium carbonate / tetrahydrofuran / 72 h / 20 °C / Reflux

3: 1-butyl-3-methylimidazolium Tetrafluoroborate; ammonium formate; tributyl-amine / palladium dichloride / 53 h / 60 °C

4: acetic anhydride; sulfuric acid / ethyl acetate / 1 h / 20 °C

5: trichlorophosphate / 60 °C

6: pyridine / acetonitrile / 50 °C

With pyridine; N-iodo-succinimide; tributyl-amine; sulfuric acid; ammonium formate; acetic anhydride; potassium carbonate; toluene-4-sulfonic acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; trichlorophosphate; palladium dichloride; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; 3: Heck Reaction;

Reference yield:

: 58456-88-5
2-iodo-4-(1-methylethyl)phenol

: 1365721-14-7
methyl 3-({[3-methyl-5-(1-methylethyl)-1-benzofuran-2-yl]sulfonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C / Reflux

2: 1-butyl-3-methylimidazolium Tetrafluoroborate; ammonium formate; tributyl-amine / palladium dichloride / 53 h / 60 °C

3: acetic anhydride; sulfuric acid / ethyl acetate / 1 h / 20 °C

4: trichlorophosphate / 60 °C

5: pyridine / acetonitrile / 50 °C

With pyridine; tributyl-amine; sulfuric acid; ammonium formate; acetic anhydride; potassium carbonate; 1-butyl-3-methylimidazolium Tetrafluoroborate; trichlorophosphate; palladium dichloride; In tetrahydrofuran; ethyl acetate; acetonitrile; 2: Heck Reaction;