3-4-ETHYLENEDIOXYPYRROLE-2,5-DICARBOXYL&

Base Information

• Chemical Name: 3-4-ETHYLENEDIOXYPYRROLE-2,5-DICARBOXYL&
• CAS No.: 169616-13-1
• Molecular Formula: C₈H₇NO₆
• Molecular Weight: 213.147
• Hs Code.: 2934999090
• Mol file: 169616-13-1.mol

Synonyms:2,3-Dihydro-6H-[1,4]dioxino[2,3-c]pyrrole-5,7-dicarboxylicacid; 3,4-Ethylenedioxypyrrole-2,5-dicarboxylic acid

Chemical Property of 3-4-ETHYLENEDIOXYPYRROLE-2,5-DICARBOXYL&

Chemical Property:

• Vapor Pressure: 9.89E-13mmHg at 25°C
• Melting Point: 137-154 °C(lit.)
• Refractive Index: 1.667
• Boiling Point: 545.5°C at 760 mmHg
• Flash Point: 283.7°C
• PSA: 108.85000
• Density: 1.75g/cm³
• LogP: 0.18230

Purity/Quality:

97% ^*data from raw suppliers

2,3-dihydro-6H-1,4-Dioxino[2,3-c]pyrrole-5,7-dicarboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-4-ETHYLENEDIOXYPYRROLE-2,5-DICARBOXYL&

There total 4 articles about 3-4-ETHYLENEDIOXYPYRROLE-2,5-DICARBOXYL& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

dimethyl 3,4-ethylenedioxypyrrole-2,5-dicarboxylate (169616-12-0) → 3,4-ethylenedioxypyrrole-2,5-dicarboxylic acid (169616-13-1)

Guidance literature:

With sodium hydroxide; In water; at 65 ℃; for 4h;

DOI:10.1055/s-1995-3993

Reference yield:

dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate (1632-19-5) → 3,4-ethylenedioxypyrrole-2,5-dicarboxylic acid (169616-13-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 2 percent / K₂CO₃ / acetone / 3.5 h / Heating

2: 86 percent / K₂CO₃ / dimethylformamide / 8 h / 130 °C

3: 73 percent / CF₃COOH/H₂SO₄, methoxybenzene / 0.5 h / 90 °C

4: 87 percent / 2N NaOH / H₂O / 4 h / 65 °C

With sodium hydroxide; sulfuric acid; potassium carbonate; methoxybenzene; trifluoroacetic acid; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1055/s-1995-3993

Reference yield:

dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (148528-45-4) → 3,4-ethylenedioxypyrrole-2,5-dicarboxylic acid (169616-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 8 h / 130 °C

2: 73 percent / CF₃COOH/H₂SO₄, methoxybenzene / 0.5 h / 90 °C

3: 87 percent / 2N NaOH / H₂O / 4 h / 65 °C

With sodium hydroxide; sulfuric acid; potassium carbonate; methoxybenzene; trifluoroacetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1055/s-1995-3993

upstream raw materials:

dimethyl 3,4-ethylenedioxypyrrole-2,5-dicarboxylate

dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate

dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate

dimethyl 1-benzyl-3,4-ethylenedioxypyrrole-2,5-dicarboxylate

Downstream raw materials:

3,4-ethylenedioxypyrrole

Refernces