(2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

Base Information

Chemical Name:(2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine
CAS No.:1037222-60-8
Molecular Formula:C₁₆H₂₀F₂N₂O₂
Molecular Weight:310.344
Hs Code.:

Synonyms:(2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

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Technology Process of (2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

There total 1 articles about (2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 220141-71-9
1‐(chloromethyl)‐3,5‐difluorobenzene

: 1037222-60-8
(2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Reference yield: 85.0%

: 1037222-60-8
(2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine

: 473567-59-8
methyl (S)-2-amino-3-(3,5-difluorophenyl)propanoate

Guidance literature:: (2S,5R)-2,5-dihydro-3,6-dimethoxy-5-isopropyl-2-(3,5-difluoro)benzylpyrazine; With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 4h;

With water; sodium hydrogencarbonate; In acetonitrile;