(S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane

Base Information

• Chemical Name: (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane
• CAS No.: 853685-27-5
• Molecular Formula: C₁₇H₂₄Si
• Molecular Weight: 256.463
• Mol file: 853685-27-5.mol

Synonyms:(S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane

Chemical Property of (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane

There total 16 articles about (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-3-(4-methyl-2-((trimethylsilyl)ethynyl)phenyl)butanal (853685-32-2) + methyl-triphenylphosphonium iodide (2065-66-9) → (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane (853685-27-5)

Guidance literature:

methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

(S)-3-(4-methyl-2-((trimethylsilyl)ethynyl)phenyl)butanal; In tetrahydrofuran; at -78 - 0 ℃; Further stages.;

DOI:10.1021/jo701935s

Reference yield: 98.0%

(S)-3-(4-methyl-2-((trimethylsilyl)ethynyl)phenyl)butanal (853685-32-2) + triphenyl(methyl)phosphonium (15912-74-0) → (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane (853685-27-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.03.184

Reference yield: 82.3%

trifluoromethanesulfonic acid 1-{2-[4-methyl-2-(trimethylsilanylethynyl)phenyl]propyl}vinyl ester (856242-91-6) → (S)-trimethyl((5-methyl-2-(pent-4-en-2-yl)phenyl)ethynyl)silane (853685-27-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; lithium chloride; tri-n-butyl-tin hydride; In tetrahydrofuran; at 60 ℃; for 0.5h;

DOI:10.1021/ja0305407

upstream raw materials:

trifluoromethanesulfonic acid 1-{2-[4-methyl-2-(trimethylsilanylethynyl)phenyl]propyl}vinyl ester

(S)-3-(4-methyl-2-((trimethylsilyl)ethynyl)phenyl)butanal

triphenyl(methyl)phosphonium

(S)-3-(4-methyl-2-((trimethylsilyl)ethynyl)phenyl)butan-1-ol

Downstream raw materials:

2-ethynyl-4-methyl-1-(1-methylbut-3-enyl)benzene