3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

Base Information

Chemical Name:3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid
CAS No.:1609009-15-5
Molecular Formula:C₁₂H₉N₅O₃
Molecular Weight:271.235
Hs Code.:

Synonyms:3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

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Chemical Property of 3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

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Technology Process of 3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

There total 6 articles about 3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₁₂H₈ClN₅O₂

: 1609009-15-5
3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Microwave irradiation; Sealed tube;

Reference yield: 92.0%

: 1609009-14-4
ethyl 3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoate

: 1609009-15-5
3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

Guidance literature:: ethyl 3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoate; With potassium hydroxide; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm401844c

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1609009-15-5
3-(5-methyl-7-oxo-6,7-dihydro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / water; 2-methyl-propan-1-ol / 150 °C / Microwave irradiation

2: hydrogenchloride; sodium nitrite / water; dichloromethane / 0.5 h / 20 °C

3: sodium acetate / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

4: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

With hydrogenchloride; sodium acetate; potassium hydroxide; sodium nitrite; In dichloromethane; 2-methyl-propan-1-ol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401844c