[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane
CAS No.:226949-15-1
Molecular Formula:C₂₈H₃₉N₃O₃Si
Molecular Weight:493.721
Hs Code.:

[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-<i>tert</i>-butyl-diphenyl-silane

Synonyms:[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

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Chemical Property of [3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

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Technology Process of [3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

There total 2 articles about [3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 226949-13-9
5-(tert-butyl-diphenyl-silanyloxy)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-pent-3-en-1-ol

: 226949-15-1
[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: With Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 0 ℃; for 18h;
DOI:10.1055/s-1999-2711

Reference yield:

: 192370-24-4
(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-pent-3-enoic acid ethyl ester

: 226949-15-1
[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / LAH / tetrahydrofuran / 0 °C

2: 77 percent / Zn(N₃)2-2Pyr, DIAD, PPh₃ / toluene / 18 h / 0 °C

With lithium aluminium tetrahydride; Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1055/s-1999-2711

Reference yield:

: 226949-15-1
[3-(2-azido-ethyl)-5-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-tert-butyl-diphenyl-silane

: 226949-19-5
1-[5-azido-3-(2-hydroxy-ethyl)-pent-2-enyl]-3-benzoyl-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / TBAF / tetrahydrofuran

2: 95 percent / DEAD, PPh₃ / tetrahydrofuran / 0 °C

3: 95 percent / p-TsOH / ethanol

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;
DOI:10.1055/s-1999-2711