(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

Base Information

Chemical Name:(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol
CAS No.:1239362-35-6
Molecular Formula:C₂₀H₂₁FN₆O
Molecular Weight:380.425
Hs Code.:

Synonyms:(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

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Chemical Property of (S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

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Technology Process of (S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

There total 4 articles about (S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354807-11-6
(S)-4-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,6-diamine

: 3-hydroxyazetidine hydrochloric acid

: 1239362-35-6
(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

Guidance literature:: 3-hydroxyazetidine hydrochloric acid; With sodium t-butanolate; In methanol;

(S)-4-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,6-diamine; With sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 16063-69-7
2,4,6-trichloropyridine

: 1239362-35-6
(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 42 h / 120 °C

2.1: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 19 h / 100 °C / Inert atmosphere

3.1: sodium t-butanolate / methanol

3.2: 1 h / 100 °C / Inert atmosphere

With potassium phosphate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; methanol; butan-1-ol;

Reference yield:

: 66399-30-2
(S)-1-(4-Fluoro-phenyl)-ethylamine

: 1239362-35-6
(S)-1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl}azetidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 42 h / 120 °C

2.1: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 19 h / 100 °C / Inert atmosphere

3.1: sodium t-butanolate / methanol

3.2: 1 h / 100 °C / Inert atmosphere

With potassium phosphate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; methanol; butan-1-ol;