1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A

Base Information

• Chemical Name: 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A
• CAS No.: 69783-64-8
• Molecular Formula: C₃₆H₄₄N₄O₁₇
• Molecular Weight: 804.762
• Mol file: 69783-64-8.mol

Synonyms:1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A

Chemical Property of 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A

There total 2 articles about 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Kanamycin A sulfate (3847-27-6,25389-94-0,64013-70-3,81129-79-5,84278-20-6,94108-19-7,94237-36-2,133-92-6) → 1,3-di-N-benzyloxycarbonyl-6',4':3'',4''-di-N,O-carbonyl-kanamycin A (1067640-80-5) + 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A (69783-64-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.07.022

Reference yield:

1,3,6',2''-tetra-N-benzyloxycarbonyl-kanamycin A (5605-66-3) → 1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A (69783-64-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00190a015

Reference yield: 92.0%

1,3-di-N-benzyloxycarbonyl-6',4':3'',2''-di-N,O-carbonyl-kanamycin A (69783-64-8) → C36H50N6O17 (1067641-33-1)

Guidance literature:

With pyridine; ammonia; In methanol; at 50 ℃; for 6h;

DOI:10.1016/j.tet.2008.07.022

upstream raw materials:

1,3,6',2''-tetra-N-benzyloxycarbonyl-kanamycin A

Kanamycin A sulfate

Downstream raw materials:

1L-N,N'-bis-benzyloxycarbonyl-O⁴-(3-amino-N,O²-carbonyl-O⁴,O⁶-cyclohexane-1,1-diyl-α-D-3-deoxy-glucopyranosyl)-O⁶-(6-amino-N,O⁴-carbonyl-α-D-6-deoxy-glucopyranosyl)-2-deoxy-streptamine

1,3-di-N-benzyloxycarbonyl-6',4'-N,O-carbonyl-kanamycin A

1,3-di-N-benzyloxycarbonyl-3''-N-(aminoformyl)-6',4'-N,O-carbonyl-kanamycin A

C₃₆H₅₀N₆O₁₇