Technology Process of 2,5-diferrocenyl-1-phenyl-1H-pyrrole
There total 3 articles about 2,5-diferrocenyl-1-phenyl-1H-pyrrole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(CH3)3CLi; (CH3)3OK;
tetrakis(triphenylphosphine) palladium(0);
In
hexane; pentane;
(N2; addn. of tBuLi in pentane to ferrocene and KOtBu in THF at -30°C, stirring for 1 h, addn. of zinc compd., keeping at -30°C for 1 h and at 298 K for 1 h, addn. of palladium compd. and pyrrole deriv., stirring at 60°C for 48 h; evapn., dissolving in CH2Cl2, washing with water, drying over MgSO4, evapn., chromy. (alumina, n-hexane/toluene (1:1)), evapn., elem. anal.;
DOI:10.1021/om100914m
- Guidance literature:
-
ferrocene;
With
n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; pentane;
at -80 ℃;
for 1h;
Inert atmosphere;
With
zinc chloride*2(tetrahydrofuran);
In
tetrahydrofuran; pentane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
2,5-dibromo-1-phenyl-1H-pyrrole;
With
C24H54Cl2P2Pd2(2+);
In
tetrahydrofuran; pentane;
at 60 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/om4007533
