7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:247237-91-8
Molecular Formula:C₁₈H₁₅ClN₂O₅
Molecular Weight:374.78
Hs Code.:

Synonyms:7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

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Chemical Property of 7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of 7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 8 articles about 7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 39787-83-2
2-methoxy-4-nitrobenzoyl chloride

: 160129-45-3
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

: 247237-91-8
7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With pyridine;
DOI:10.1016/S0968-0896(99)00101-7

Reference yield:

: 5202-89-1
4-chlorobenzenesulfonyl chloride

: 247237-91-8
7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / pyridine / 20 °C

2.1: 94 percent / K₂CO₃ / dimethylformamide / 4 h / 120 °C

3.1: t-BuOK / toluene / 0.5 h / Heating

3.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating

4.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C

5.1: 92 percent / pyridine

With pyridine; PPA; potassium tert-butylate; potassium carbonate; In N,N-dimethyl-formamide; toluene; 1.1: Tosylation / 2.1: Alkylation / 3.1: Cyclization / 3.2: Hydrolysis / 4.1: detosylation / 5.1: Acylation;
DOI:10.1016/S0968-0896(99)00101-7

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 247237-91-8
7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / K₂CO₃ / acetone / 0.5 h / Heating

2.1: SnCl₂*2H₂O; conc. HCl / ethanol / 20 °C

3.1: 85 percent / pyridine / 20 °C

4.1: 94 percent / K₂CO₃ / dimethylformamide / 4 h / 120 °C

5.1: t-BuOK / toluene / 0.5 h / Heating

5.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating

6.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C

7.1: 92 percent / pyridine

With pyridine; hydrogenchloride; PPA; potassium tert-butylate; potassium carbonate; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide; acetone; toluene; 1.1: Esterification / 2.1: Reduction / 3.1: Tosylation / 4.1: Alkylation / 5.1: Cyclization / 5.2: Hydrolysis / 6.1: detosylation / 7.1: Acylation;
DOI:10.1016/S0968-0896(99)00101-7