(R)-2-(Pyrrolidin-1-yl)propan-1-ol

Base Information

• Chemical Name: (R)-2-(Pyrrolidin-1-yl)propan-1-ol
• CAS No.: 169308-05-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.202
• European Community (EC) Number: 867-124-2
• Mol file: 169308-05-8.mol

Synonyms:169308-05-8;(R)-2-(Pyrrolidin-1-yl)propan-1-ol;(2R)-2-pyrrolidin-1-ylpropan-1-ol;(2R)-2-(pyrrolidin-1-yl)propan-1-ol;1-Pyrrolidineethanol,beta-methyl-,(betaR)-(9CI);SCHEMBL6183540;TQP0788;OIINYTXPBGXEEH-SSDOTTSWSA-N;MFCD18835082;F89848;EN300-3418954

Chemical Property of (R)-2-(Pyrrolidin-1-yl)propan-1-ol

Chemical Property:

• PSA: 23.47000
• LogP: 0.40090
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 79

Purity/Quality:

(R)-2-(Pyrrolidin-1-yl)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)N1CCCC1
• Isomeric SMILES: C[C@H](CO)N1CCCC1

Technology Process of (R)-2-(Pyrrolidin-1-yl)propan-1-ol

There total 2 articles about (R)-2-(Pyrrolidin-1-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1,4-dibromo-butane (110-52-1) + (R)-2-aminopropan-1-ol (35320-23-1) → (R)-2-(pyrrolidin-1-yl)propan-1-ol (169308-05-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1016/j.bmcl.2004.10.036

Reference yield:

→ (R)-2-(pyrrolidin-1-yl)propan-1-ol (169308-05-8)

Guidance literature:

Reference yield:

(R)-2-(pyrrolidin-1-yl)propan-1-ol (169308-05-8) + (+)-4-((2S,3R)-6-(benzyloxy)-3-{3-[(triisopropylsilyl) oxy] phenyl}-2,3-dihydro-1,4-benzoxathiin-2-yl)phenol (412052-05-2) → (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-((S)-1-methyl-2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol + (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-((R)-2-pyrrolidin-1-yl-propoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol

Guidance literature:

(R)-2-(pyrrolidin-1-yl)propan-1-ol; (+)-4-((2S,3R)-6-(benzyloxy)-3-{3-[(triisopropylsilyl) oxy] phenyl}-2,3-dihydro-1,4-benzoxathiin-2-yl)phenol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

With ammonium formate; palladium; In ethanol; water; ethyl acetate;

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.10.036

upstream raw materials:

1,4-dibromo-butane

(R)-2-aminopropan-1-ol

Downstream raw materials:

3-(3-hydroxyphenyl)-4-methyl-2-(4-((R)-2-(pyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol trifluoroacetate