2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

Base Information

Chemical Name:2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine
CAS No.:328233-75-6
Molecular Formula:C₄₉H₆₈N₂Si
Molecular Weight:713.178
Hs Code.:

2-(3,5-di-<i>tert</i>-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

Synonyms:2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

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Chemical Property of 2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

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Technology Process of 2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

There total 5 articles about 2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 328233-71-2
2-(3,5-di-tert-butyl-phenylethynyl)-5-ethynyl-pyrimidine

: 1-iodo-4-(trimethylsilylethynyl)-2,5-dioctylbenzene

: 328233-75-6
2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In tetrahydrofuran; for 6h; Heating;
DOI:10.1021/ol006877k

Reference yield:

: 36720-94-2
1,3-di-tert-butyl-5-ethynylbenzene

: 328233-75-6
2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(PPh₃)4; CuI; i-Pr₂NH / tetrahydrofuran / 2.5 h / 30 °C

2: i-Pr₂NH / tetrahydrofuran / 1.5 h / Heating

3: 2N NaOH / tetrahydrofuran; methanol / 0.33 h / 20 °C

4: 94 percent / Pd(PPh₃)4; CuI; i-Pr₂NH / tetrahydrofuran / 6 h / Heating

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling reaction / 2: Sonogashira coupling reaction / 4: Sonogashira coupling reaction;
DOI:10.1021/ol006877k

Reference yield:

: 5-bromo-2-(3,5-di-tert-butyl-phenylethynyl)-pyrimidine

: 328233-75-6
2-(3,5-di-tert-butyl-phenylethynyl)-5-(2,5-dioctyl-4-trimethylsilanylethynyl-phenylethynyl)-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: i-Pr₂NH / tetrahydrofuran / 1.5 h / Heating

2: 2N NaOH / tetrahydrofuran; methanol / 0.33 h / 20 °C

3: 94 percent / Pd(PPh₃)4; CuI; i-Pr₂NH / tetrahydrofuran / 6 h / Heating

With sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling reaction / 3: Sonogashira coupling reaction;
DOI:10.1021/ol006877k