[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Base Information

Chemical Name:[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid
CAS No.:1450758-70-9
Molecular Formula:C₂₄H₃₀N₄O₄
Molecular Weight:438.527
Hs Code.:

Synonyms:[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Suppliers and Price of [2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

There total 13 articles about [2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl 4-[(1S,2S)-2-(2-{[5-(2-tert-butoxy-2-oxoethyl)pyrimidin-2-yl]amino}ethyl)cyclopropyl]piperidine-1-carboxylate

: 1450758-70-9
[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Guidance literature:: benzyl 4-[(1S,2S)-2-(2-{[5-(2-tert-butoxy-2-oxoethyl)pyrimidin-2-yl]amino}ethyl)cyclopropyl]piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; pH=Ca. 5;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1450758-70-9
[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen; quinoline / ethyl acetate / 0.67 h

3.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

3.2: 0.17 h / -20 °C / Inert atmosphere

3.3: 24 h / -20 - 0 °C / Inert atmosphere

4.1: hydrogen; 20% palladium hydroxide-activated charcoal / ethyl acetate; ethanol / 0.5 h / 3345.86 Torr

5.1: sodium periodate / dichloromethane; water / 0.5 h / 0 °C / Cooling with ice

6.1: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7.2: 20 °C

8.1: triethylamine / ethyl acetate / 5 h / 20 °C / Reflux

9.1: dipotassium hydrogenphosphate; sodium carbonate; codexis BS₃ / water; dimethyl sulfoxide; methanol / 7 h / 0 - 25 °C / pH 7 - 8 / Enzymatic reaction

9.2: 0.5 h / 5 - 40 °C / pH Ca_. 10

10.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

11.1: acetic acid / methanol; tetrahydrofuran / 0.17 h / 20 °C

11.2: MP-CN BH₃ / 20 °C

12.1: trifluoroacetic acid / dichloromethane / 20 °C

12.2: 0 °C / pH Ca_. 5

With quinoline; hydrogenchloride; sodium tetrahydroborate; sodium periodate; dipotassium hydrogenphosphate; n-butyllithium; 20% palladium hydroxide-activated charcoal; codexis BS₃; hydrogen; diethylzinc; sodium carbonate; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1402554-67-9
benzyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1450758-70-9
[2-({2-[(1S,2S)-2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}cyclopropyl]ethyl}amino)pyrimidin-5-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

2.1: acetic acid / methanol; tetrahydrofuran / 0.17 h / 20 °C

2.2: MP-CN BH₃ / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: 0 °C / pH Ca_. 5

With Dess-Martin periodane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;