(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

Base Information

Chemical Name:(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate
CAS No.:1187055-32-8
Molecular Formula:C₂₅H₃₀N₂O₆
Molecular Weight:454.523
Hs Code.:

Synonyms:(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

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Chemical Property of (3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

Chemical Property:

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Technology Process of (3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

There total 10 articles about (3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1187055-31-7
(3S,5S)-benzyl 3-azido-5-(benzoyloxy)piperidine-1-carboxylate

: 1187055-32-8
(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

Guidance literature:: (3S,5S)-benzyl 3-azido-5-(benzoyloxy)piperidine-1-carboxylate; With ammonium hydroxide; trimethylphosphane; In pyridine; at 20 ℃; for 3h;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; at 0 - 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₂₀H₂₂N₂O₄

: 1187055-32-8
(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water; at 0 - 20 ℃;

Reference yield:

: 825644-52-8
(3R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-piperidine-1-carboxylic acid benzyl ester

: 1187055-32-8
(3S,5S)-benzyl 3-(benzoyloxy)-5-(tert-butoxycarbonylamino)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / methanol; isopropyl alcohol / 3 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: sodium azide / 1-methyl-pyrrolidin-2-one / 80 °C

5.1: pyridine; ammonium hydroxide; trimethylphosphane / 3 h / 20 °C

6.1: sodium hydrogencarbonate / tetrahydrofuran; 1,4-dioxane; water / 0 - 20 °C

With pyridine; hydrogenchloride; ammonium hydroxide; sodium azide; di-tert-butyl-diazodicarboxylate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; isopropyl alcohol;