1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• CAS No.: 1026156-23-9
• Molecular Formula: C₂₇H₃₂N₄O₆
• Molecular Weight: 508.574

Synonyms:1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property of 1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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Technology Process of 1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 1 articles about 1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-methoxyphenyl)piperazine (38212-30-5) + ethyl 1-(t-butyl)-7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (148927-29-1) → 1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1026156-23-9)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1021/jm9903390

Reference yield:

1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1026156-23-9) → 6-amino-1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (304897-90-3)

Guidance literature:

With hydrogen; nickel; In 2-methoxy-ethanol; N,N-dimethyl-formamide; at 20 ℃; for 4h; under 1558.1 Torr;

DOI:10.1021/jm9903390

Reference yield:

1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1026156-23-9) → 6-amino-1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney nickel / dimethylformamide; 2-methoxy-ethanol / 4 h / 20 °C / 1558.1 Torr

2: aq.NaOH / 3.5 h / Heating

With sodium hydroxide; hydrogen; nickel; In 2-methoxy-ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9903390

upstream raw materials:

4-(4-methoxyphenyl)piperazine

ethyl 1-(t-butyl)-7-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Downstream raw materials:

6-amino-1-tert-butyl-7-[4-(4-methoxy-phenyl)-piperazin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

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