N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

Base Information

Chemical Name:N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide
CAS No.:1034974-86-1
Molecular Formula:C₂₉H₃₂F₂N₆O₄S
Molecular Weight:598.674
Hs Code.:

Synonyms:N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

There total 13 articles about N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.45%

: 109-01-3
1-methyl-piperazine

: 4-bromo-N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-benzamide

: 1034974-86-1
N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

Guidance literature:: With palladium diacetate; lithium diisopropyl amide; ruphos; In tetrahydrofuran; at 60 ℃; Inert atmosphere; Large scale;

Reference yield:

: 1034974-60-1
N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-4-{[2-(isopropyl-methyl-amino)-ethyl]-methyl-amino}-2-(tetrahydro-pyran-4-ylamino)-benzamide

: 1034974-86-1
N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; copper(l) iodide / diethylene glycol; isopropyl alcohol / 0.85 - 60 °C / Inert atmosphere; Reflux; Large scale

2: pyridine / dichloromethane / -15 °C / Large scale

3: Oxone / acetonitrile; water / 40 °C / Large scale

4: triethylamine / methanol / 50 °C / Large scale

5: palladium diacetate; ruphos; lithium diisopropyl amide / tetrahydrofuran / 60 °C / Inert atmosphere; Large scale

With pyridine; Oxone; copper(l) iodide; palladium diacetate; potassium carbonate; triethylamine; lithium diisopropyl amide; ruphos; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; acetonitrile; diethylene glycol;

Reference yield:

: 4-bromo-2-((R)-2-methoxy-1-methyl-ethylamino)-benzoic acid tert-butyl ester

: 1034974-86-1
N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: dichloromethane / -10 °C / Large scale

2: trifluoroacetic acid / dichloromethane / 22 °C / Large scale

3: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 22 °C / Large scale

4: pyridine / dichloromethane / -15 °C / Large scale

5: Oxone / acetonitrile; water / 40 °C / Large scale

6: triethylamine / methanol / 50 °C / Large scale

7: palladium diacetate; ruphos; lithium diisopropyl amide / tetrahydrofuran / 60 °C / Inert atmosphere; Large scale

With pyridine; Oxone; oxalyl dichloride; palladium diacetate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium diisopropyl amide; ruphos; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;