N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

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Chemical Name:N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
CAS No.:1262798-99-1
Molecular Formula:C₂₁H₁₈F₆N₆O₃
Molecular Weight:516.403
Hs Code.:

N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Synonyms:N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

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Chemical Property of N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

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Technology Process of N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

There total 18 articles about N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262799-50-7
tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

: 1262798-99-1
N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1262799-40-5
(S)-1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone oxime

: 1262798-99-1
N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: hydroquinone / xylenes / 22 h / 140 °C

2: zinc; acetic acid / 0 - 20 °C

3: chromium(VI) oxide; sulfuric acid / water; acetone / 72 h / 20 °C

4: sulfuric acid / 20 °C / Inert atmosphere; Reflux

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

6: nitric acid / 24 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

8: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C

9: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

10: trifluoroacetic acid / dichloromethane / 20 °C

With chromium(VI) oxide; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; sulfuric acid; hydrogen; nitric acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydroquinone; trifluoroacetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; xylenes;

Reference yield:

: 1262799-38-1
(S)-N-methoxy-N-methyl-2-(( 1,1,1-trifluorobut-3-en-2-yl)oxy)acetamide

: 1262798-99-1
N-(3-((4aS,5S,7aS)-2-amino-3-ethyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -78 - -60 °C / Inert atmosphere

1.2: 2 h / -60 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 50 °C

3.1: hydroquinone / xylenes / 22 h / 140 °C

4.1: zinc; acetic acid / 0 - 20 °C

5.1: chromium(VI) oxide; sulfuric acid / water; acetone / 72 h / 20 °C

6.1: sulfuric acid / 20 °C / Inert atmosphere; Reflux

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

8.1: nitric acid / 24 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

12.1: trifluoroacetic acid / dichloromethane / 20 °C

With chromium(VI) oxide; n-butyllithium; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; sulfuric acid; hydroxylamine hydrochloride; hydrogen; nitric acid; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydroquinone; trifluoroacetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; xylenes;