2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate

Base Information

• Chemical Name: 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate
• CAS No.: 1061353-83-0
• Molecular Formula: C₂HF₃O₂*C₂₆H₂₈F₃N₅O₃
• Molecular Weight: 629.559
• Mol file: 1061353-83-0.mol

Synonyms:2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate

Chemical Property of 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate

There total 3 articles about 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-4-morpholinoaniline (209960-91-8) + C15H13ClF3N3O (1061358-66-4) + trifluoroacetic acid (76-05-1) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate (1061353-83-0)

Guidance literature:

2-methoxy-4-morpholinoaniline; C₁₅H₁₃ClF₃N₃O; With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 - 100 ℃; for 4h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

4-(3-methoxy-4-nitro-phenyl)morpholine (6950-88-5) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate (1061353-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 90 - 100 °C / Microwave irradiation

With hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; 2: Buchwald-Hartwig amination;

Reference yield:

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → 2-(2-(2-methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N,N-dimethylbenzamide trifluoroacetate (1061353-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 90 - 100 °C / Microwave irradiation

With hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 3: Buchwald-Hartwig amination;

upstream raw materials:

2-methoxy-4-morpholinoaniline

C₁₅H₁₃ClF₃N₃O

trifluoroacetic acid

4-(3-methoxy-4-nitro-phenyl)morpholine