benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

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Chemical Name:benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate
CAS No.:918547-81-6
Molecular Formula:C₃₉H₃₉ClN₄O₄S
Molecular Weight:695.282
Hs Code.:

Synonyms:benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

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Chemical Property of benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

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Technology Process of benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

There total 5 articles about benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918547-60-1
benzyl 2-(9-(3-aminobenzyl)-3-chloro-9H-carbazol-7-yl)propanoate

: 58-85-5,22879-79-4
biotin

: 918547-81-6
benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

Guidance literature:: biotin; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl 2-(9-(3-aminobenzyl)-3-chloro-9H-carbazol-7-yl)propanoate; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm0610200

Reference yield:

: 166408-09-9
benzyl 2-(3-chloro-9H-carbazol-7-yl)propionate

: 918547-81-6
benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 70 percent / tetrahydrofuran / 20 °C

2.1: SnCl₂; ethanol / 3 h / Heating

3.1: Et₃N / dimethylformamide / 0.17 h / 20 °C

3.2: ethyl-(3'-dimethylaminopropyl)carbodiimide hydrochloride; N-hydroxybenzotriazole hydrate / dimethylformamide / 0.5 h / 20 °C

3.3: 72 mg / Et₃N / dimethylformamide / 18 h / 20 °C

With ethanol; sodium hydride; triethylamine; tin(ll) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0610200

Reference yield:

: 918547-61-2
benzyl 2-(6-chloro-9-(3-nitrobenzyl)-9H-carbazol-2-yl)propanoate

: 918547-81-6
benzyl 2-(9-(3-(5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-6-yl)pentanamido)benzyl)-3-chloro-9H-carbazol-7-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: SnCl₂; ethanol / 3 h / Heating

2.1: Et₃N / dimethylformamide / 0.17 h / 20 °C

2.2: ethyl-(3'-dimethylaminopropyl)carbodiimide hydrochloride; N-hydroxybenzotriazole hydrate / dimethylformamide / 0.5 h / 20 °C

2.3: 72 mg / Et₃N / dimethylformamide / 18 h / 20 °C

With ethanol; triethylamine; tin(ll) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm0610200