(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

Base Information

Chemical Name:(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol
CAS No.:329914-10-5
Molecular Formula:C₄₆H₈₄O₅Si₃
Molecular Weight:801.426
Hs Code.:

Synonyms:(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

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Chemical Property of (2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

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Technology Process of (2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

There total 1 articles about (2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329914-08-1
(4S,5S,6R)-9-benzyloxy-4,6-dimethyl-5-(triethylsilyl)oxy-2-nonynal

: C₁₆H₃₂SiO₂SiC₆H₁₃CeCl₂

: 329914-10-5
(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.75h;
DOI:10.1021/jo0056951

Reference yield: 86.0%

: 329914-10-5
(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

: 329914-11-6
(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-one

Guidance literature:: With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; In dichloromethane; for 0.5h;
DOI:10.1021/jo0056951

Reference yield:

: 329914-10-5
(2S,5S,6R,12S,13S,14R)-2,6,12,14-tetramethyl-1-(tert-butyldimethylsilyl)oxy-5,13-(triethylsilyl)oxy-17-benzyloxy-7,10-heptadecyn-9-ol

: 329914-13-8
(2S,5S,6R,12S,13S,14R)-17-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-2,6,12,14-tetramethyl-5,13-bis-triethylsilanyloxy-heptadecan-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / tetrapropylammonium perruthenate; NMO; 4 Angstroem MS / CH₂Cl₂ / 0.5 h

2: 95 percent / H₂ / Pd/CaCO₃/Pb / ethyl acetate

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; Lindlar's catalyst; In dichloromethane; ethyl acetate;
DOI:10.1021/jo0056951