4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Base Information

Chemical Name:4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
CAS No.:1572928-34-7
Molecular Formula:C₁₅H₁₈F₃N₃O₂S
Molecular Weight:361.388
Hs Code.:

Synonyms:4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

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Chemical Property of 4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Chemical Property:

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Technology Process of 4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

There total 5 articles about 4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-33-6
benzyl 3-(1-propyn-1-yl)-4-(4-((2,2,2-trifluoroethyl)sulfamoyl)phenyl)-1-piperazinecarboxylate

: 1572928-34-7
4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Guidance literature:: With sulfuric acid; In chloroform; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

: 934810-99-8
4-bromo-N-(2,2,2-trifluoroethyl)benzenesulfonamide

: 1572928-34-7
4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

2: sulfuric acid / chloroform / 3 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; sodium t-butanolate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In 1,4-dioxane; chloroform;

Reference yield:

: 1361224-49-8
benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate

: 1572928-34-7
4-(2-(1-propyn-1-yl)-1-piperazinyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.25 h / -10 - 20 °C

1.2: 2 h

2.1: 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

3.1: sulfuric acid / chloroform / 3 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; trifluoroacetic acid; sodium t-butanolate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In 1,4-dioxane; dichloromethane; chloroform;