(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid

Base Information

• Chemical Name: (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid
• CAS No.: 693790-33-9
• Molecular Formula: C₂₈H₃₄O₅Si
• Molecular Weight: 478.66
• Mol file: 693790-33-9.mol

Synonyms:(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid

Chemical Property of (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid

There total 2 articles about (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid methyl ester (693790-04-4) → (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid (693790-33-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

DOI:10.1139/v03-199

Reference yield:

(S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate (124655-05-6) → (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid (693790-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / camphorsulfonic acid / CH₂Cl₂ / 72 h / 20 °C

2: 90 percent / LiOH / tetrahydrofuran; methanol / 48 h / 20 °C

With lithium hydroxide; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1139/v03-199

Reference yield: 93.0%

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid (693790-33-9) → (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyramide (693790-06-6)

Guidance literature:

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With ammonium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1139/v03-199

upstream raw materials:

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid methyl ester

(S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

Downstream raw materials:

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyramide

(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)thiobutyramide

(R)-2-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}propan-1-ol

(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyraldehyde