{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

Base Information

Chemical Name:{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid
CAS No.:1332895-52-9
Molecular Formula:C₁₁H₁₄Cl₂NO₅P
Molecular Weight:342.116
Hs Code.:

Synonyms:{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

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Chemical Property of {1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

Chemical Property:

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Technology Process of {1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

There total 6 articles about {1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1332895-45-0
{4-[(benzyloxy)(methyl)amino]-1-(3,4-dichlorophenyl)-4-oxobutyl}phosphonic acid

: 1332895-52-9
{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 1500.15 Torr;
DOI:10.1021/jm200694q

Reference yield:

: 1332895-28-9
diethyl [1-(3,4-dichlorophenyl)-4-oxobutyl]phosphonate

: 1332895-52-9
{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: selenium(IV) oxide; dihydrogen peroxide / tetrahydrofuran / 4 h / 65 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.75 h / 20 °C

2.2: 20 °C

3.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

3.2: 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 1500.15 Torr

With selenium(IV) oxide; trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200694q

Reference yield:

: 1332895-36-9
diethyl {4-[(benzyloxy)(methyl)amino]-1-(3,4-dichlorophenyl)-4-oxobutyl}phosphonate

: 1332895-52-9
{1-(3,4-dichlorophenyl)-4-[hydroxy(methyl)amino]-4-oxobutyl}phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1500.15 Torr

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;
DOI:10.1021/jm200694q