3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

Base Information

Chemical Name:3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one
CAS No.:1314380-62-5
Molecular Formula:C₂₀H₁₈N₆O₂
Molecular Weight:374.402
Hs Code.:

Synonyms:3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

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Chemical Property of 3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

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Technology Process of 3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

There total 8 articles about 3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314388-85-6
3-(chloromethyl)-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

: 1314389-90-6
5-methoxy-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrimidine

: 1314380-62-5
3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 100 ℃; for 1.16667h; Inert atmosphere;

Reference yield:

: 1314389-91-7
2-(3-chlorophenyl)-5-methoxypyrimidine

: 1314380-62-5
3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1.17 h / 100 °C / Inert atmosphere

With potassium phosphate; potassium acetate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1314380-62-5
3-[3-(5-methoxypyrimidin-2-yl)benzyl]-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.25 h / 100 °C / Inert atmosphere

2: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1.17 h / 100 °C / Inert atmosphere

With potassium phosphate; potassium acetate; sodium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; water;