methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate
CAS No.:1402466-26-5
Molecular Formula:C₂₀H₂₀N₄O₂
Molecular Weight:348.404
Hs Code.:

Synonyms:methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

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Chemical Property of methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

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Technology Process of methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

There total 4 articles about methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402466-25-4
methyl 1-(6-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

: 105675-85-2
4-bromo-2-methyl-2H-pyrazol-3-ylamine

: 1402466-26-5
methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 100 ℃; for 1h;

Reference yield:

: 39891-09-3
(6-chloro-pyridin-3-yl)-acetonitrile

: 1402466-26-5
methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-Bromo-2-chloroethane; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / 50 °C

1.2: 100 °C

2.1: sulfuric acid / Reflux

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C

4.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C

With potassium phosphate; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; 1-Bromo-2-chloroethane; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water;

Reference yield:

: 854267-90-6
1-(6-chloropyridin-3-yl)cyclopropanecarboxylic acid

: 1402466-26-5
methyl 1-(6-(4-(5-amino-1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-3-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C

3: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C

With potassium phosphate; sulfuric acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water;