4-CHLORO-2,6-DI(2-PYRIDINYL)PYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-2,6-DI(2-PYRIDINYL)PYRIMIDINE
• CAS No.: 10198-68-2
• Molecular Formula: C₁₄H₉ClN₄
• Molecular Weight: 268.705
• Mol file: 10198-68-2.mol

Synonyms:4-Chloro-2,6-bis(2-pyridinyl)pyrimidine

Chemical Property of 4-CHLORO-2,6-DI(2-PYRIDINYL)PYRIMIDINE

Chemical Property:

• Boiling Point: 366.7±42.0 °C(Predicted)
• PKA: -0.51±0.19(Predicted)
• Density: 1.311±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2,6-bis(pyridin-2-yl)pyrimidine 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-CHLORO-2,6-DI(2-PYRIDINYL)PYRIMIDINE

There total 4 articles about 4-CHLORO-2,6-DI(2-PYRIDINYL)PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-hydroxy-2,6-bis(2-pyridyl)pyrimidine (10239-68-6) → 4-Chloro-2,6-bis(2-pyridinyl)pyrimidine (10198-68-2)

Guidance literature:

With thionyl chloride; at 75 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.inorgchem.6b02496

Reference yield:

pyridine-2-carboxamidine hydrochloride (51285-26-8,61097-49-2) → 4-Chloro-2,6-bis(2-pyridinyl)pyrimidine (10198-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol / 72 h / 20 °C / Inert atmosphere; Schlenk technique

2: thionyl chloride / 75 °C / Inert atmosphere; Schlenk technique

With thionyl chloride; sodium hydroxide; In ethanol; water;

DOI:10.1021/acs.inorgchem.6b02496

Reference yield:

ethyl 2-pyridylcarbonylacetate (26510-52-1) → 4-Chloro-2,6-bis(2-pyridinyl)pyrimidine (10198-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol / 72 h / 20 °C / Inert atmosphere; Schlenk technique

2: thionyl chloride / 75 °C / Inert atmosphere; Schlenk technique

With thionyl chloride; sodium hydroxide; In ethanol; water;

DOI:10.1021/acs.inorgchem.6b02496

upstream raw materials:

pyridine-2-carboxamidine hydrochloride

ethyl 2-pyridylcarbonylacetate

4-hydroxy-2,6-bis(2-pyridyl)pyrimidine

Downstream raw materials:

4-(3-Methoxyanilino)-2,6-di(2-pyridinyl)pyrimidine

4-(2,5-Dimethoxyanilino)-2,6-di(2-pyridinyl)pyrimidine

4-(2-Methoxy-5-methylanilino)-2,6-di(2-pyridinyl)pyrimidine

Refernces