3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

Base Information

Chemical Name:3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one
CAS No.:74280-94-7
Molecular Formula:C₂₀H₂₄N₂O₆S
Molecular Weight:420.486
Hs Code.:

Synonyms:3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

Suppliers and Price of 3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

There total 1 articles about 3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74280-93-6
1,2-secopenicillin tosylate

: 13831-31-7
Acetoxyacetyl chloride

: 74280-94-7
3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; at -40 - 0 ℃; for 0.666667h;
DOI:10.1021/jo01306a028

Reference yield:

: 74280-94-7
3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

: 74280-96-9
3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4α-chloroazetidin-2-one

Guidance literature:: With chlorine; In tetrachloromethane; dichloromethane; 1) -78 deg C, 40 min, 2) 0 deg C, 20 min;
DOI:10.1021/jo01306a028

Reference yield:

: 74280-94-7
3β-(Acetoxyacetamido)-1-<1-((benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)azetidin-2-one

: 74281-15-5
7-<(Z)-2-(Methoxyimino)-2-phenylacetamido>-1-oxa-2-oxocepham-4α-carboxylic Acid

Guidance literature:: Multi-step reaction with 16 steps

1: 5.50 g / Cl₂ / CH₂Cl₂; CCl₄ / 1) -78 deg C, 40 min, 2) 0 deg C, 20 min

2: 3.35 g / Ag₂O, AgBF₄ / tetrahydrofuran / 1) -30 deg C, 2) -15 deg C, 2.5h, 3) room temperature, 1h

3: 36 percent / K₂CO₃ / acetone; H₂O / 3 h / 55 °C

4: 68 percent / Pyridine / CH₂Cl₂ / 1) -35 deg C -> 0 deg C, 1h, 2) 0 deg C, 1h

5: 0.880 g / Pyridine / tetrahydrofuran / 1.5 h / -78 deg C -> room temp.

6: 0.730 g / camphorsulfonic acid, H₂O / CH₂Cl₂ / 0.58 h / Ambient temperature

7: 80 percent / O₃ / ethyl acetate / -78 °C

8: 1.49 g / Zn dust, propionic acid / CH₂Cl₂ / 0.5 h / 1) 0 deg C -> 13 deg C, 30 min, 2) 0 deg C after 30 min

9: 1.31 g / 2,6-Lutidine, SOCl₂ / CH₂Cl₂ / 1) -30 deg C -> 0 deg C , 20 min, 2) 0 deg C, 1.5h

10: 0.99 g / CH₂Cl₂ / 1) 12 h, room temperature, 2) 4.5 h heating

11: 75 percent / Zn dust, acetic acid / CH₂Cl₂ / 5 h / 15 °C

12: 85 percent / acetic anhydride / dimethylsulfoxide / 4 h / Ambient temperature

14: 1) DMF, POCl₃, 2) Pyridine

15: 0.102 g / Zn dust, AcOH / CH₂Cl₂ / 0.33 h / Ambient temperature

16: 0.125 g / H₂ / palladium black / ethyl acetate; ethanol / 0.25 h

With pyridine; 2,6-dimethylpyridine; silver tetrafluoroborate; thionyl chloride; camphor-10-sulfonic acid; water; hydrogen; acetic anhydride; chlorine; potassium carbonate; ozone; acetic acid; propionic acid; N,N-dimethyl-formamide; silver(l) oxide; zinc; trichlorophosphate; palladium; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone;
DOI:10.1021/jo01306a028