(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one
CAS No.:172225-74-0
Molecular Formula:C₂₅H₂₉NO₆
Molecular Weight:439.508
Hs Code.:

Synonyms:(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Chemical Property:

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Technology Process of (4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

There total 1 articles about (4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 109066-05-9
3-(methoxymethoxy)propionaldehyde

: (4R,5S)-4-methyl-5-phenyl-3-((E)-4-phenylbut-3-enoyl)oxazolidin-2-one

: 172225-74-0
(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane;
DOI:10.1248/cpb.43.1598

Reference yield: 80.0%

: 172225-74-0
(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 172225-75-1
(2S,3S)-5-Methoxymethoxy-2-((E)-styryl)-pentane-1,3-diol

Guidance literature:: With lithium borohydride; tributyl borane; In tetrahydrofuran; acetic acid;
DOI:10.1248/cpb.43.1598

Reference yield:

: 172225-74-0
(4R,5S)-3-[(2R,3S)-3-Hydroxy-5-methoxymethoxy-2-((E)-styryl)-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 162473-78-1
desepoxyarenastatin A

Guidance literature:: Multi-step reaction with 13 steps

1: 80 percent / Bu₃B, LiBH₄ / tetrahydrofuran; acetic acid

2: puridine

3: LiB(Et)3H / tetrahydrofuran

4: HCl / methanol

5: imidazole

6: 90 percent / Et₃N, DMAP / CH₂Cl₂

7: n-Bu₄NF, AcOH

8: Dess-Martin periodinate

9: NaH / dimethylformamide

10: PhSH, BF₃*OEt₂ / -50 °C

11: IPCF, Et₃N, DMAP / CH₂Cl₂

12: 1.) TFA, 2.) HCl

13: diphenylphosphoryl azide, NaHCO₃ / dimethylformamide / 36 h / 0 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; lithium borohydride; tributyl borane; boron trifluoride diethyl etherate; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; sodium hydride; lithium triethylborohydride; sodium hydrogencarbonate; Dess-Martin periodane; acetic acid; isopropyl chloroformate; thiophenol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.1598