1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

Base Information

Chemical Name:1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline
CAS No.:96965-51-4
Molecular Formula:C₂₀H₂₇NO₇S
Molecular Weight:425.503
Hs Code.:

Synonyms:1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

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Chemical Property of 1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

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Technology Process of 1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

There total 4 articles about 1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 96965-58-1
(S)-1-[2-(1-Ethoxycarbonyl-3-phenyl-propane-1-sulfonyl)-propionyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

: 96965-51-4
1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/jm00147a030

Reference yield:

: 96965-40-1
ethyl α-<(1-carboxyethyl)thio>benzenebutanoate

: 96965-51-4
1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 30percent H₂O₂ / acetic acid

2: 28 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 0 - 25 °C

3: 54 percent / trifluoroacetic acid / 3.5 h / 0 - 20 °C

With dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00147a030

Reference yield:

: 96965-38-7
ethyl α-<<2-(1,1-dimethylethoxy)-1-methyl-2-oxoethyl>thio>benzenebutanoate

: 96965-51-4
1-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>sulfonyl>-1-oxopropyl>-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / trifluoroacetic acid / 1.5 h

2: 30percent H₂O₂ / acetic acid

3: 28 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / dimethylformamide / 0 - 25 °C

4: 54 percent / trifluoroacetic acid / 3.5 h / 0 - 20 °C

With dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00147a030