dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

Base Information

Chemical Name:dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate
CAS No.:553668-51-2
Molecular Formula:C₃₄H₅₀N₄O₆
Molecular Weight:610.794
Hs Code.:

Synonyms:dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

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Chemical Property of dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

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Technology Process of dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

There total 3 articles about dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 373-44-4
1,8-diaminooctan

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 553668-51-2
dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

Guidance literature:: (S)-N-(benzyloxycarbonyl)valine; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

1,8-diaminooctan; In tetrahydrofuran; at 0 - 20 ℃; for 12.25h; Inert atmosphere;
DOI:10.1016/j.bmcl.2018.02.005

Reference yield: 95.0%

: 3496-11-5
2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate

: 373-44-4
1,8-diaminooctan

: 553668-51-2
dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

Guidance literature:: In 1,2-dimethoxyethane; at 55 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c5cc04281j

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 553668-51-2
dibenzyl ((2S,2'R)-(octane-1,8-diylbis(azanediyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / DCC / tetrahydrofuran / 3 h / 0 - 5 °C

2: 86 percent / 1,2-dimethoxy-ethane / 24 h / 20 - 50 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/ja0284759