N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Base Information

• Chemical Name: N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine
• CAS No.: 160107-22-2
• Molecular Formula: C₃₈H₄₁N₆O₉P
• Molecular Weight: 756.752
• Mol file: 160107-22-2.mol

Synonyms:N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property of N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

There total 9 articles about N₂-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-O-levulinoylthymidine (78635-98-0) + 5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite (141846-56-2,149198-11-8,103001-00-9,103001-83-8,93183-15-4) → C53H59N8O15P + N2-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (160107-22-2)

Guidance literature:

3'-O-levulinoylthymidine; 5'-O-dimethoxytrityl-N₂-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite; With poly(4-vinylpyridinium-p-toluenesulfonate); In dichloromethane; at 20 ℃; for 2h;

With poly(4-vinylpyridinium-p-toluenesulfonate); water; In dichloromethane; for 0.5h; Title compound not separated from byproducts;

DOI:10.1021/ol0511777

Reference yield:

3'-O-levulinoylthymidine (78635-98-0) + 5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite (141846-56-2,149198-11-8,103001-00-9,103001-83-8,93183-15-4) → C53H59N8O15PS + N2-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (160107-22-2)

Guidance literature:

3'-O-levulinoylthymidine; 5'-O-dimethoxytrityl-N₂-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite; With poly(4-vinylpyridinium-p-toluenesulfonate); In dichloromethane; at 20 ℃; for 2h;

With poly(4-vinylpyridinium-p-toluenesulfonate); water; In dichloromethane; for 0.5h;

With Amberlyst A-26 tetrathionate; In dichloromethane; at 20 ℃; for 1.58333h; Title compound not separated from byproducts;

DOI:10.1021/ol0511777

Reference yield:

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-cytidine (91592-66-4) + 5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite (141846-56-2,149198-11-8,103001-00-9,103001-83-8,93183-15-4) → N2-isobutyryl-3'-O-(2-cyanoethyl)-phosphonate-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine (160107-22-2) + C59H62N9O15P (402920-18-7)

Guidance literature:

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-cytidine; 5'-O-dimethoxytrityl-N₂-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite; With poly(4-vinylpyridinium-p-toluenesulfonate); In dichloromethane; at 20 ℃; for 2h;

With poly(4-vinylpyridinium-p-toluenesulfonate); water; In dichloromethane; for 0.5h; Title compound not separated from byproducts;

DOI:10.1021/ol0511777

upstream raw materials:

3'-O-levulinoylthymidine

5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-cytidine

N²-isobutyryl-3'-O-levulinyl-2'-deoxyguanosine

Downstream raw materials:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

C₃₅H₃₈N₅O₉P