tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

Base Information

Chemical Name:tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate
CAS No.:145485-79-6
Molecular Formula:C₃₈H₄₇N₃O₆
Molecular Weight:641.808
Hs Code.:

tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

Synonyms:tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

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Chemical Property of tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

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Technology Process of tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

There total 10 articles about tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97278-68-7,86499-24-3
3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine

: 145485-79-6
tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / 5percent Pt/C / methanol / 4.5 h / 2068.6 Torr / Ambient temperature

2: 87 percent / diisopropylethylamine, BOP / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) sodium hydride / 1.) DMF, 15 min, 2.) DMF, RT, 16 h

With hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00033a006

Reference yield:

: 4879-95-2
4,4-dimethyl-azetidin-2-one

: 145485-79-6
tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, DMPA / CH₂Cl₂ / Ambient temperature

2: 87 percent / 1.0 M aq. lithium hydroxide / tetrahydrofuran / 2 h / 0 - 5 °C

3: 87 percent / diisopropylethylamine, BOP / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) sodium hydride / 1.) DMF, 15 min, 2.) DMF, RT, 16 h

With lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00033a006

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 145485-79-6
tert-butyl 4'-<<3-<(3-tert-butoxycarbonyl)amino>-3-methyl-1-oxobutyl>amino>-<<2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-1-yl>methyl><1,1'-biphenyl>-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine, DMPA / CH₂Cl₂ / Ambient temperature

2: 87 percent / 1.0 M aq. lithium hydroxide / tetrahydrofuran / 2 h / 0 - 5 °C

3: 87 percent / diisopropylethylamine, BOP / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) sodium hydride / 1.) DMF, 15 min, 2.) DMF, RT, 16 h

With lithium hydroxide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00033a006