3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI)
• CAS No.: 167626-78-0
• Molecular Formula: C7H8 N2 O2
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• Mol file: 167626-78-0.mol

Synonyms:6-Amino-5-methylnicotinicacid

Chemical Property of 3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI)

Chemical Property:

• Boiling Point: 371.3±42.0 °C(Predicted)
• PKA: 2.93±0.10(Predicted)
• PSA: 76.94000
• Density: 1.337±0.06 g/cm3(Predicted)
• LogP: 0.60050
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-AMINO-5-METHYLNICOTINIC ACID 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI)

There total 2 articles about 3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-amino-5-methyl-pyridine-3-carbonitrile (183428-91-3) → 6-amino-5-methyl-pyridine-3-carboxylic acid (167626-78-0)

Guidance literature:

With water; sodium hydroxide; for 4h; Reflux;

Reference yield:

5-bromo-3-methyl-pyridin-2-ylamine (3430-21-5) → 6-amino-5-methyl-pyridine-3-carboxylic acid (167626-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 120 °C / Inert atmosphere

2: sodium hydroxide / water / 4 h / Reflux

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield: 62.0%

6-amino-5-methyl-pyridine-3-carboxylic acid (167626-78-0) + 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine (1428929-08-1,1428954-51-1) → 6-amino-5-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl] methylene]cyclohexyl]pyridine-3-carboxamide (1428926-94-6,1428947-73-2,1428949-42-1)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2018.11.048

upstream raw materials:

6-amino-5-methyl-pyridine-3-carbonitrile

5-bromo-3-methyl-pyridin-2-ylamine

Downstream raw materials:

6-amino-5-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl] methylene]cyclohexyl]pyridine-3-carboxamide

Refernces

• 1、 -. "AMIDE COMPOUNDS, COMPOSITIONS AND APPLICATIONS THEREOF". Page/Page column 83. . Retrieved 2013/04/10.