Z-FY-Cho

Base Information

• Chemical Name: Z-FY-Cho
• CAS No.: 167498-29-5
• Molecular Formula: C₂₆H₂₆N₂O₅
• Molecular Weight: 446.503
• UNII: U433S6RM7M
• Nikkaji Number: J741.980E
• Pharos Ligand ID: KR76K2BCDG9W
• ChEMBL ID: CHEMBL177914
• Mol file: 167498-29-5.mol

Synonyms:N-(benzyloxycarbonyl)-phenylalanyl-tyrosinal;Z-FY-CHO;Z-Phe-Tyr-al

Chemical Property of Z-FY-Cho

Chemical Property:

• Boiling Point: 726.5±60.0 °C(Predicted)
• PKA: 9.87±0.15(Predicted)
• PSA: 104.73000
• Density: 1.249±0.06 g/cm3(Predicted)
• LogP: 3.93790
• Storage Temp.: -15°C
• Solubility.: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)
• XLogP3: 3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 11
• Exact Mass: 446.18417193
• Heavy Atom Count: 33
• Complexity: 608

Purity/Quality:

99%+, ^*data from raw suppliers

Z-Phe-Tyr-aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=C(C=C2)O)C=O)NC(=O)OCC3=CC=CC=C3
• Isomeric SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=C(C=C2)O)C=O)NC(=O)OCC3=CC=CC=C3
• Description: Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over ?cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic ?pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2

Technology Process of Z-FY-Cho

There total 2 articles about Z-FY-Cho which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(S)-1-[(S)-2-(4-Hydroxy-phenyl)-1-(3-methyl-thiazolidin-2-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester → N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal (167498-29-5)

Guidance literature:

With water; copper(II) oxide; copper dichloride; In acetonitrile;

DOI:10.1016/S0040-4039(97)00383-3

Reference yield:

{(S)-1-[(S)-2-(4-tert-Butoxy-phenyl)-1-(3-methyl-thiazolidin-2-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester → N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal (167498-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: CuO, CuCl₂, H₂O / acetonitrile

With water; trifluoroacetic acid; copper(II) oxide; copper dichloride; In acetonitrile;

DOI:10.1016/S0040-4039(97)00383-3

Refernces