6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Base Information

• Chemical Name: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS No.: 789445-02-9
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 789445-02-9.mol

Synonyms:6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Chemical Property of 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

There total 4 articles about 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (693273-07-3) + 1,1-Dimethyl-3-phenyl-propylamin (43052-72-8) → 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (789445-02-9)

Guidance literature:

6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one; 1,1-dimethyl-3-phenylpropanamine; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

With methanol; sodium tetrahydroborate; Further stages; Cooling with ice;

DOI:10.1016/j.bmc.2019.115178

Reference yield:

4-phenyl-2-methyl-2-butanol (103-05-9) → 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (789445-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 3 h / Cooling with ice

2.1: potassium hydroxide / ethylene glycol / 15 h / 200 °C

3.1: dimethyl sulfoxide / 1.5 h / 20 °C

3.2: Cooling with ice

With sulfuric acid; potassium hydroxide; In ethylene glycol; dimethyl sulfoxide; 1.1: |Ritter Amidation;

DOI:10.1016/j.bmc.2019.115178

Reference yield:

N-[1,1-dimethyl-3-phenylpropyl]acetamide (79399-13-6) → 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (789445-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethylene glycol / 15 h / 200 °C

2.1: dimethyl sulfoxide / 1.5 h / 20 °C

2.2: Cooling with ice

With potassium hydroxide; In ethylene glycol; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2019.115178

upstream raw materials:

4-phenyl-2-methyl-2-butanol

N-[1,1-dimethyl-3-phenylpropyl]acetamide

6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

1,1-Dimethyl-3-phenyl-propylamin