1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID

Base Information

• Chemical Name: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID
• CAS No.: 167479-16-5
• Molecular Formula: C10H9 N O2
• Molecular Weight: 175.187
• Hs Code.: 2933990090
• Mol file: 167479-16-5.mol

Synonyms:N-Methyl-7-indolylcarboxylicacid

Chemical Property of 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 389.0±15.0 °C(Predicted)
• PKA: 4.59±0.10(Predicted)
• PSA: 42.23000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 1.87650
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-1H-indole-7-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID

There total 15 articles about 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-methyl-1H-indole-2,7-dicarboxylic acid (167479-20-1) → 1-methylindolyl-7-carboxylic acid (167479-16-5)

Guidance literature:

With quinoline; copper(II) oxide; at 180 ℃; for 1h;

DOI:10.1248/cpb.47.1538

Reference yield:

methyl 1-methyl-1H-indole-7-carboxylate (167479-21-2) → 1-methylindolyl-7-carboxylic acid (167479-16-5)

Guidance literature:

With sodium hydroxide; In methanol; water; for 8h; Heating;

DOI:10.3987/COM-05-S(T)38

Reference yield:

benzyl 1-methylindole-7-carboxylate (208772-25-2) → 1-methylindolyl-7-carboxylic acid (167479-16-5)

Guidance literature:

upstream raw materials:

1-methyl-1H-indole-2,7-dicarboxylic acid

ethyl 1-methylindole-7-carboxylate

methyl 1-methyl-1H-indole-7-carboxylate

ethyl 1H-indole-7-carboxylate

Refernces

• 1、 Rigby, James H.,Burke, Patrick J.. "Synthesis of highly substituted indole alkaloid species via [4+1] cyclization of nucleophilic carbenes and indole isocyanates". . p. 643 - 653. Retrieved 2007/10/03.
• 2、 -. "Pyrrolidine modulators of chemokine receptor activity". . . Retrieved 2008/06/13.