4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid
• CAS No.: 1208170-02-8
• Molecular Formula: C₁₄H₁₅N₃O₂S
• Molecular Weight: 289.358
• Mol file: 1208170-02-8.mol

Synonyms:4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid

Chemical Property of 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid

Chemical Property:

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Technology Process of 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid

There total 1 articles about 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylate (1208170-01-7) → 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid (1208170-02-8)

Guidance literature:

ethyl 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylate; With water; sodium hydroxide; In ethanol; for 2h; Reflux;

With acetic acid; In water;

Reference yield: 74.0%

4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid (1208170-02-8) → 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxamide (1208170-03-9)

Guidance literature:

4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylic acid; With 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h;

With ammonium hydroxide; In N,N-dimethyl-formamide; for 0.333333h;

upstream raw materials:

ethyl 4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxylate

Downstream raw materials:

4-methyl-6-[(3-methylphenyl)amino]-2-(methylthio)-5-pyrimidinecarboxamide