6-Carboxy-6-phenylpiperidin-2-one

Base Information

Chemical Name:6-Carboxy-6-phenylpiperidin-2-one
CAS No.:167398-76-7
Molecular Formula:C12H13 N O3
Molecular Weight:219.24
Hs Code.:
DSSTox Substance ID:DTXSID50437206
Mol file:167398-76-7.mol

Synonyms:167398-76-7;2-Piperidinecarboxylicacid, 6-oxo-2-phenyl-;2-Piperidinecarboxylic acid, 6-oxo-2-phenyl-;6-OXO-2-PHENYLPIPERIDINE-2-CARBOXYLIC ACID;6-carboxy-6-phenylpiperidin-2-one;DTXSID50437206

Suppliers and Price of 6-Carboxy-6-phenylpiperidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6-Carboxy-6-phenylpiperidin-2-one

Chemical Property:

Boiling Point:495.3±45.0 °C(Predicted)
PKA:3.11±0.20(Predicted)
PSA：69.89000
Density:1.261±0.06 g/cm3(Predicted)
LogP:1.54250
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:219.08954328
Heavy Atom Count:16
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC(C1)(C2=CC=CC=C2)C(=O)O

Technology Process of 6-Carboxy-6-phenylpiperidin-2-one

There total 4 articles about 6-Carboxy-6-phenylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 167398-57-4
6-ethoxycarbonyl-6-phenylpiperidin-2-one

: 167398-76-7
6-carboxy-6-phenylpiperidin-2-one

Guidance literature:: With potassium hydroxide; In ethanol; Ambient temperature;
DOI:10.1016/0223-5234(94)90068-X

Reference yield:

: 6097-58-1,6152-27-8,15962-49-9,39251-40-6
ethyl 2-phenyl-2-aminoacetate

: 167398-76-7
6-carboxy-6-phenylpiperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / MgSO₄ / toluene / 48 h / Ambient temperature

2: NaH / dimethylformamide

3: 10percent aq. HCl / 1 h

4: 81 percent / KOH / aq. ethanol / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydride; magnesium sulfate; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(94)90068-X

Reference yield:

: 77290-52-9
N-benzyliden-2-phenylglycine ethyl ester

: 167398-76-7
6-carboxy-6-phenylpiperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: 10percent aq. HCl / 1 h

3: 81 percent / KOH / aq. ethanol / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90068-X