3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

Base Information

Chemical Name:3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid
CAS No.:123749-06-4
Molecular Formula:C₁₃H₂₂O₂
Molecular Weight:210.316
Hs Code.:

Synonyms:3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

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Chemical Property of 3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

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Technology Process of 3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

There total 10 articles about 3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 472-66-2
(2,6,6-trimethyl-1-cyclohexen-1-yl)acetaldehyde

: 123749-06-4
3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, 1 h, 2.) 45 min

2: 70 percent / LAH / benzene; tetrahydrofuran / 1 h / Ambient temperature

3: 71 percent / Ti(OiPr)4/(-)-diethyl D-tartrate, t-BuOOH / tetrahydrofuran / -20 °C

4: pyridine / 0 - 5 °C

5: NaI / acetone / 1.5 h / Heating

6: Zn, AcOH / 2 h

7: KH, 18-crown-6 / 1,2-dimethoxy-ethane / 3 h / Heating

8: AgNO₃ / ethanol; H₂O / 4 h

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; 18-crown-6 ether; diethyl (2S,3S)-tartrate; potassium hydride; sodium hydride; silver nitrate; acetic acid; sodium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetone; benzene;

Reference yield:

: 432-25-7
2,6,6-trimethylcyclohex-1-enecarbaldehyde

: 123749-06-4
3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 61 percent / tetrahydrofuran / 1 h / Ambient temperature

2: 94 percent / 60percent perchloric acid / tetrahydrofuran / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) THF, 1 h, 2.) 45 min

4: 70 percent / LAH / benzene; tetrahydrofuran / 1 h / Ambient temperature

5: 71 percent / Ti(OiPr)4/(-)-diethyl D-tartrate, t-BuOOH / tetrahydrofuran / -20 °C

6: pyridine / 0 - 5 °C

7: NaI / acetone / 1.5 h / Heating

8: Zn, AcOH / 2 h

9: KH, 18-crown-6 / 1,2-dimethoxy-ethane / 3 h / Heating

10: AgNO₃ / ethanol; H₂O / 4 h

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; perchloric acid; 18-crown-6 ether; diethyl (2S,3S)-tartrate; potassium hydride; sodium hydride; silver nitrate; acetic acid; sodium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetone; benzene;

Reference yield:

: 86558-54-5,86558-55-6
2-((E)-2-Methoxy-vinyl)-1,3,3-trimethyl-cyclohexene

: 123749-06-4
3-((S)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-propionic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / 60percent perchloric acid / tetrahydrofuran / 0.5 h / Ambient temperature

2: 1.) NaH / 1.) THF, 1 h, 2.) 45 min

3: 70 percent / LAH / benzene; tetrahydrofuran / 1 h / Ambient temperature

4: 71 percent / Ti(OiPr)4/(-)-diethyl D-tartrate, t-BuOOH / tetrahydrofuran / -20 °C

5: pyridine / 0 - 5 °C

6: NaI / acetone / 1.5 h / Heating

7: Zn, AcOH / 2 h

8: KH, 18-crown-6 / 1,2-dimethoxy-ethane / 3 h / Heating

9: AgNO₃ / ethanol; H₂O / 4 h

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; perchloric acid; 18-crown-6 ether; diethyl (2S,3S)-tartrate; potassium hydride; sodium hydride; silver nitrate; acetic acid; sodium iodide; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetone; benzene;