Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-

Base Information

Chemical Name:Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-
CAS No.:167299-12-9
Molecular Formula:C20H20 N4 O3
Molecular Weight:364.4
Hs Code.:
Mol file:167299-12-9.mol

Synonyms:Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-

Suppliers and Price of Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-

Chemical Property:

PSA：101.45000
LogP:2.42520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)-

There total 1 articles about Benzeneacetamide, N-(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 2034-31-3
6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione

: 167299-12-9
N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-benzyl-2-phenyl-acetamide

Guidance literature:: With dmap; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm9608467

Reference yield:

: 167299-12-9
N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-benzyl-2-phenyl-acetamide

: (6aR,9aS)-3-(cyclohexylmethyl)-5,6a,7,8,9,9a-hexahydro-5-methyl-2-(phenylmethyl)cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: POCl₃ / 7 h / Heating

2: diisopropylethylamine / various solvent(s) / 130 °C

3: SOCl₂ / CH₂Cl₂ / 3 h / Ambient temperature

4: ammonium formate / 20percent Pd(OH)2/C / methanol / Heating

5: 51 percent / K₂CO₃ / dimethylformamide / 20 h / 60 °C

With thionyl chloride; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9608467

Reference yield:

: 167299-12-9
N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-benzyl-2-phenyl-acetamide

: (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-2-(phenylmethyl)-3-[(2,3-dihydroxyphenyl)methyl]cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: POCl₃ / 7 h / Heating

2: diisopropylethylamine / various solvent(s) / 130 °C

3: SOCl₂ / CH₂Cl₂ / 3 h / Ambient temperature

4: ammonium formate / 20percent Pd(OH)2/C / methanol / Heating

5: K₂CO₃ / dimethylformamide / 20 h / 60 °C

6: 30 percent / BBr₃ / CH₂Cl₂ / 18 h / -78 - 20 °C

With thionyl chloride; ammonium formate; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9608467