methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

Base Information

Chemical Name:methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate
CAS No.:530089-12-4
Molecular Formula:C₂₅H₂₅ClF₂N₂O₃
Molecular Weight:474.935
Hs Code.:

Synonyms:methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

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Chemical Property of methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

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Technology Process of methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

There total 2 articles about methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183171-54-2
methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

: C₁₂H₁₃Cl₂NO

: 530089-12-4
methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1016/j.bmc.2009.10.038

Reference yield:

: 530089-12-4
methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

Guidance literature:

Reference yield: 92.0%

: 530089-12-4
methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

: 1225281-59-3
C₂₄H₂₃ClF₂N₂O₃

Guidance literature:: methyl (2Z)-2-(1-{2-chloro-4-[(3S)-3-methylpyrrolidin-1-yl]benzoyl}-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate; With water; sodium hydroxide; In methanol; at 20 ℃; for 14h;

With hydrogenchloride; In methanol; chloroform; water;
DOI:10.1016/j.bmc.2009.10.038