(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

Base Information

Chemical Name:(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal
CAS No.:129360-72-1
Molecular Formula:C₂₁H₁₈F₂N₂O
Molecular Weight:352.384
Hs Code.:

Synonyms:(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

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Chemical Property of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

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Technology Process of (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

There total 3 articles about (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 129360-69-6
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

: 129360-72-1
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00075a020

Reference yield:

: 129360-64-1
4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole

: 129360-72-1
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / tetrahydrofuran / 65 h / Heating

2: 81 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

3: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

With manganese(IV) oxide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00075a020

Reference yield:

: 129359-41-7
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester

: 129360-72-1
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

2: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

With manganese(IV) oxide; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/jm00075a020