(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

Base Information

Chemical Name:(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate
CAS No.:185814-12-4
Molecular Formula:C₂₂H₂₈N₄O₄
Molecular Weight:412.489
Hs Code.:

Synonyms:(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

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Chemical Property of (6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

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Technology Process of (6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

There total 4 articles about (6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: methyl 4-[2(2-pivaloylamino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)ethenyl]benzoate

: 185814-12-4
(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 29h; under 2585.74 Torr;
DOI:10.1039/b505907k

Reference yield:

: 1075-49-6
4-ethenylbenzoic acid

: 185814-12-4
(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / aq. H₂SO₄ / 9 h / Heating

2: 92 percent / tri-o-tolylphosphine; Et₃N / Pd(OAc)2 / acetonitrile / 30 h / Heating

3: 74 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 29 h / 2585.74 Torr

With sulfuric acid; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile; 2: Heck reaction;
DOI:10.1039/b505907k

Reference yield:

: 1076-96-6
methyl 4-vinylbenzoate

: 185814-12-4
(6RS)-methyl 4-[2-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / tri-o-tolylphosphine; Et₃N / Pd(OAc)2 / acetonitrile / 30 h / Heating

2: 74 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 29 h / 2585.74 Torr

With hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile; 1: Heck reaction;
DOI:10.1039/b505907k