{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

Base Information

Chemical Name:{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid
CAS No.:1095274-37-5
Molecular Formula:C₁₄H₁₄ClN₃O₄
Molecular Weight:323.736
Hs Code.:

Synonyms:{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

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Chemical Property of {5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

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Technology Process of {5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

There total 7 articles about {5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-36-4
ethyl {5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

: 1095274-37-5
{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2010.01.012

Reference yield:

: 1095274-32-0
3-chloro-5-(4-morpholinyl)benzoic acid

: 1095274-37-5
{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 4 h

1.2: 20 °C / pH 7

2.1: hydrazine / ethanol / 4 h / Heating / reflux

3.1: tetrahydrofuran / 0.5 h / 20 °C

4.1: Burgess Reagent / dichloromethane / 0.17 h / 100 °C / Microwave irradition

5.1: sodium hydroxide; water / ethanol / 0.33 h / 20 °C

With sodium hydroxide; Burgess Reagent; water; hydrazine; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 327056-73-5
3-fluoro-5-chlorobenzonitrile

: 1095274-37-5
{5-[3-chloro-5-(4-morpholinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 - 80 °C

2.1: sodium hydroxide / ethanol; water / Heating / reflux

2.2: pH 5 - 6

3.1: sulfuric acid / 4 h

3.2: 20 °C / pH 7

4.1: hydrazine / ethanol / 4 h / Heating / reflux

5.1: tetrahydrofuran / 0.5 h / 20 °C

6.1: Burgess Reagent / dichloromethane / 0.17 h / 100 °C / Microwave irradition

7.1: sodium hydroxide; water / ethanol / 0.33 h / 20 °C

With sodium hydroxide; Burgess Reagent; water; potassium carbonate; hydrazine; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;